Two sample MR report
HOMER2_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0136703 | 0.0920242 | 0.8913310 |
| Weighted median | 5 | 0.0325688 | 0.0073274 | 0.0000088 |
| Inverse variance weighted | 5 | 0.0325870 | 0.0059190 | 0.0000000 |
| Simple mode | 5 | 0.0352395 | 0.0096228 | 0.0215411 |
| Weighted mode | 5 | 0.0297997 | 0.0095193 | 0.0351700 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0406301 | 3 | 0.9978482 |
| Inverse variance weighted | 0.2943512 | 4 | 0.9901759 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0513385 | 0.1019213 | 0.6491285 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.73e-05 | 0 | TRUE | 0.3809127 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
